Strategies for the Production of Molecular Animations

Perspective article in: Frontiers in Bioinformatics, May 16th 2022, https://doi.org/10.3389/fbinf.2022.793914

Building-integrated photovoltaics

Animation created for the Competence Centre Photovoltaics Berlin (PVcomB) at the Helmholtz Zentrum Berlin (HZB)

Protein structure portrait: NMNAT

Three crystal structures of NMNAT, each in a different ligand binding state, allow the prediction of a reaction mechanism for the enzymatic production of NAD+ from NMN and ATP.

Showreel 2000

Take a tour through the exhibition of RNS Berlin animations.

From protein to medicine

Five animations created for the Berlin Science Week Talk by Manfred Weiss, Helmholtz Zentrum Berlin on November 4th 2020.

Membrane constriction by Dynamin

The Dynamin tetramer binds a membrane and forms a filament, a right-handed helix around a membrane tube. The proposed stepping mechanism for membrane constriction involves a power stroke, that pulls the helical turns against each other, each step reducing the membrane tube radius by approximately 1 nm.

Project for and with: Katja Faelber, Jeffrey Noel and Oliver Daumke - Max Delbrück Center for Molecular Medicine (MDC), Berlin

Illustration of data flow: collection, analysis and output generation.

The animation shows an illustrated data flow and includes the steps (a) data collection through selection at an interface in various categories, (b) color coded data transfer and analysis at a data centre and (c) the output generation of the analysed data.

Potential membrane remodelling by Mgm1

Mitochondrial genome maintenance protein 1 (Mgm1) is thought to create filaments preferring a left-handed helix and positive curvature. In this geometry, a dynamin-like power stroke would lead to an expansion of the filament, and thus, an expansion of the membrane tube. However, Mgm1 may create other filament geometries and bind a membrane surface with negative curvature.
Project for and with: Katja Faelber, Jeffrey Noel and Oliver Daumke - Max Delbrück Center for Molecular Medicine (MDC), Berlin. An extract of this animation was published as supplementary video in Faelber et al. Nature, 571:429-433 (2019).

Sustainability and Dimensions

Regenerative energy is sustainable.