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Protein structure portrait: NMNAT



Nicotinamide mononucleotide adenylyltransferase (NMNAT) is a nuclear protein that catalyses the reaction NMN + ATP >> NAD + PPi. Three crystal structures of NMNAT were published in 2002 and show different ligand binding states. One represents the apoenzyme (1kku), a second binds NMN (1gzu) and a third NAD (1kqn). The conformational changes between those three structures allow a detailed view on the molecular reaction mechanism and the enzyme behaviour. In the cell, NMNAT occurs as hexamer which plays a role in attracting the ligands in the first place.

status: July 2020






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